Connective Tissue Disease

 Ehlers-Danlos syndrome

The problems present in Ehlers-Danlos syndrome (EDS), a group of more than 10 disorders, include changes in the physical properties of skin, joints, blood vessels, and other tissues such as ligaments and tendons.

People with EDS have some degree of joint looseness, fragile small blood vessels, and abnormal scar formation and wound healing. Soft, velvety skin stretches excessively but returns to normal after being pulled.

Some forms of EDS can present problems with the spine, including a curved spine, and the eyes. EDS can also lead to weak internal organs, including the uterus, intestines, and large blood vessels. Mutations in several different genes are responsible for varying symptoms in the several types of EDS. In most cases, the genetic defect involves collagen, the major protein-building material of bone.


Oral Manifestations of Ehlers-Danlos Syndrome

Ehlers-Danlos, Kyphoscoliotic Type, NIH

, Vascular Type, NIH

Ehlers Danlos
Orthopaedics and Sports Medicine, University of Washington

Ehlers Danlos, Arthritis Foundation

About Ehlers Danlos, University of Washington

Treatment of Ehlers-Danlos syndrome focuses on managing symptoms and preventing complications. it may include the following:

  • Physical therapy.
  • Drugs.
  • Surgery.
  • Follow-up.
  • Genetic consultation and counseling.

See in more detail at Mayo Clinic

Some other Common Heritable Disorders of Connective Tissue


list of publications from Mayo Clinic about Ehlers-Danlos syndrome on PubMed

Ehlers-Danlos, Classic Type, NIH

Ehlers-Danlos Hypermobility Type, NIH

DISCLAIMER: The information on this site is for educational purposes only, and should not be used as a substitute for treatment by a health care practitioner

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